Sheriff's Deputies initiated a traffic stop on a 2014 Cadillac Escalade on US Route 60.
Inside the SUV, they found Roxycodone pills and a large amount of cash.
Jason D. Payne, 31, of Marmet, Amanda K. Payne, 32, of Marmet, along with Brittany Ramsey, 25, of Cedar Grove, were arrested.
They are all charged with possession and conspiracy to commit a felony.
The bust led investigators to a nearby house, where they seized even more cash that was related to the drug sales.